onc201
Pediatric and adult H3 K27M-mutant diffuse midline glioma treated with the selective DRD2 antagonist ONC201
J Neurooncol. 2019 PMID: 31456142
Publications
imipridones
Defining structure activity relationships for GPCR engagement and anti-cancer efficacy of imipridone small molecules
ACR Annual Meeting 2019
onc201
Safety and enhanced immunostimulatory activity of the DRD2 antagonist ONC201 in advanced solid tumor patients with weekly oral administration
J Immunother Cancer. 2019 PMID: 31118108
imipridones
Mitochondrial ClpP-mediated proteolysis induces selective cancer cell lethality
Cancer Cell 2019 PMID: 31056398
dstat
A randomized phase II trial of CX-01 with standard therapy in elderly patients with Acute Myeloid Leukemia (AML)
Journal of Clinical Oncology 2019
onc212
Imipridone ONC212 activates orphan G protein-coupled receptor GPR132 and integrated stress response in acute myeloid leukemia.
Leukemia. 2019 PMID: 31127149
onc201
Dopamine receptor D5 is a modulator of tumor response to dopamine receptor D2 antagonism
Clin Cancer Res. 2019 PMID: 30559168
onc201
Dose intensification of TRAIL-inducing ONC201 inhibits metastasis and promotes intratumoral NK cell recruitment
J Clin Invest. 2018 PMID: 29533922
dstat
Combination of the low anticoagulant heparin CX‑01 with chemotherapy for the treatment of acute myeloid leukemia
Blood Adv. 2018
dstat
2-O, 3-O desulfated heparin mitigates murine chemotherapy- and radiation-induced thrombocytopenia
Blood Advances 2018