Dociparstat sodium, also known as DSTAT, is an investigational, intravenous treatment in development as a first-line therapy in acute myeloid leukemia (AML). Clinical studies have suggested that the combination of DSTAT with standard chemotherapy may improve outcomes for individuals with this life-threatening disease.
DSTAT may enhance eradication of leukemic blasts and dormant leukemic stem cells by flushing them out of the bone marrow and making them more sensitive to chemotherapy, reducing the potential for eventual relapse. Clearance of leukemic stem cells may translate to increased depth of response and improved long-term outcomes for patients with AML. Specifically, DSTAT may:
DSTAT has been shown to bind to platelet factor 4, which may help with hematologic recovery in patients with AML.
Read more about DSTAT and results from a Phase 2 clinical trial here.
DSTAT has received Fast Track and Orphan Drug designations from the U.S. Food and Drug Administration for the treatment of AML.
Chimerix plans to initiate a Phase 3 study of DSTAT in AML in mid-2020.