Extensive Chemical Library

Developing effective antiviral treatments demands a rigorous testing process. At Chimerix, we use our broad chemical library—which houses more than 3,000 diverse nucleotides— to tailor our therapies and build more potent antiviral therapeutics, as well as therapies for other disease states categorized by an unmet need for effective treatment.

Our chemical library contains a diverse array of heterocyclic ring system molecules, including more than 3,000 structurally diverse nucleoside derivatives. Nucleoside analogs are widely used in antiviral therapy, and are ideally suited as potential antivirals for both DNA and RNA viruses that rely on viral encoded polymerases for their replication. We are currently screening the library against a broad spectrum of DNA and RNA viruses.

Where possible, we apply our lipid conjugate technology to build potent antivirals that are orally absorbed and have favorable tissue penetration.

Our current focus is on novel nucleosides with activity against:

  • CMV and BK virus
  • Norovirus
  • Influenza
  • Viruses that have significant global impact and for which there are currently no effective treatments