At Chimerix, we’re on a mission to discover and develop much-needed medicines that protect immunocompromised patients from potentially devastating viral infections. For people with weakened immune systems and patients undergoing bone marrow transplants, common viruses can quickly become life-threatening.
More than 70,000 hematopoietic cell transplants (HCT, or bone marrow transplants) are performed each year worldwide, most frequently to treat patients with certain cancers of the blood and bone marrow, or to address genetic diseases. Due to chemotherapy and the immune suppression associated with HCT, patients are highly susceptible to viral, bacterial and fungal infections. These complications are a significant cause of morbidity and mortality in the months following the transplant, and too often the high risk of infection in the first year after transplant results in patients and their families deciding against having a potentially curative transplant.
Our goal is to develop safe and effective therapies to protect these patients from the dangers of life-threatening infections so they can remain on the path to recovery.
The ability to prevent life-threatening viruses like cytomegalovirus (CMV) in vulnerable hematopoietic cell transplant (HCT) recipients may be possible. Our proprietary technology has led us to two products currently showing great potential: brincidofovir (CMX001) and CMX157. Brincidofovir, a clinical-stage lipid conjugate nucleotide analog , has demonstrated in vitro antiviral activity against all five families of DNA viruses that affect humans, including CMV, adenovirus, BK virus and herpes simplex viruses, in an orally administered dosing regimen. CMX157, a novel lipid acyclic nucleoside phosphonate, is active against hepatitis B virus (HBV) and more than 200-fold more potent in vitro versus tenofovir against all major HIV subtypes resistant to current therapies.
Through work to date, we see opportunities to apply the lipid conjugate technology to other drug and disease categories that are also characterized by a need for effective treatments.